PCOS (NOW RENAMED PMOS)· ⚡ Out of Sync

Your cycle isn't broken. It's running a different operating system.

1 in 10 women has PCOS — now being officially renamed PMOS. Most supplements were designed for someone else.

Selene has two separate PCOS/PMOS profiles — androgen-dominant and lean. Because inositol alone doesn't cover it, and berberine is wrong for lean PCOS. The quiz figures out which you are.

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“In May 2026, a Lancet Commission voted 87–3 to rename Polycystic Ovary Syndrome to Polyendocrine Metabolic Ovarian Syndrome (PMOS) — a name that better captures what it actually is: a whole-body metabolic condition. If you were diagnosed with PCOS, that's still the name your doctor uses. Both names, same condition, same profiles. Most PCOS/PMOS supplements treat a condition as if it has one face. It has at least four phenotypes — and the androgen-dominant and lean versions have meaningfully different hormonal signatures.”

YOUR PROFILE

⚡

Out of Sync

PCOS (now renamed PMOS)

WHAT'S IN YOUR PACK

Myo-inositol + D-chiro4g / 100mg
Improves FSH receptor sensitivity and insulin signaling independent of weight. 40:1 ratio mirrors the natural tissue distribution.
Spearmint extract900mg
Reduces free testosterone via 5-alpha reductase inhibition. Two cups of spearmint tea daily reduced free T by 30% in a 2010 RCT (Grant et al.).
N-Acetyl Cysteine (NAC)600mg
Antioxidant support for follicular microenvironment; improves ovulation rate when combined with clomiphene (Rizk 2005). Removed from androgen PCOS profile on insulin phases.
Zinc bisglycinate30mg
Androgen-modulating trace mineral. Sebum regulation, hair follicle support. Low zinc is disproportionately common in PCOS.
Vitamin D3 (lichen)2000 IU
VDR expression in ovarian tissue. Deficiency independently associated with worse metabolic and hormonal markers in PCOS (Wehr 2011).
Berberine HCl500mg
AMPK activator — equivalent to metformin in some metabolic endpoints. Included for androgen-dominant PCOS only; removed for lean PCOS to avoid reactive hypoglycemia.

The androgen-dominant (Out of Sync) and lean (The Quiet Pattern) profiles share inositol, spearmint, NAC, zinc, and vitamin D. Berberine is present only in the androgen-dominant profile.

“I've read everything on PCOS supplements. When I saw inositol and spearmint on my ritual without having to ask for them, I knew the quiz actually worked.”

Sarah K.
PCOS/PMOS · New York

COMMON QUESTIONS

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