CARDIOVASCULAR HEALTH· ❤️ Heart First

Estrogen is cardioprotective. The decade after it drops is when risk catches up to men's.

Women's cardiovascular risk matches men's within 10 years of menopause — not because of aging, but because estrogen loss removes a specific vascular protection that was quietly working for decades.

Heart First targets the estrogen-cardiovascular axis directly: CoQ10 ubiquinol for cardiac mitochondrial function, algae-sourced EPA/DHA for inflammation and triglycerides, magnesium glycinate for arterial tone, NAC for endothelial antioxidant capacity, and Kyolic garlic for vascular flexibility. The window to build this foundation is before the risk curve bends.

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“A landmark 2001 meta-analysis by Mosca et al. found that women underestimate their cardiovascular risk compared to breast cancer risk — yet cardiovascular disease kills more women than all cancers combined. The protective window is estrogen. Before menopause, women have significantly lower rates of myocardial infarction and stroke. After menopause, without estrogen's vasodilatory and anti-inflammatory effects, risk equalizes rapidly. The supplement stack for this profile targets the mechanisms estrogen was performing: nitric oxide support, LDL oxidation protection, and inflammatory cytokine reduction.”

Mosca L et al., Circulation, 2004 — cardiovascular disease prevention in women guidelines

YOUR PROFILE

❤️

Heart First

Cardiovascular Health

WHAT'S IN YOUR PACK

CoQ10 (ubiquinol)200mg
Ubiquinol is the active, reduced form of CoQ10 — the mitochondrial electron carrier the heart muscle depends on for energy production. Statin medications deplete CoQ10 through the same enzyme pathway they inhibit for cholesterol; ubiquinol supplementation is recommended alongside statin therapy for this reason. Langsjoen & Langsjoen 2003: cardiac output improved measurably with ubiquinol in statin-depleted patients.
Omega-3 EPA/DHA (algae)2g
Algae-derived EPA and DHA are the cardiovascular omega-3s without the contamination variability of fish oil. EPA reduces serum triglycerides, lowers inflammatory cytokines (IL-6, TNF-α), and decreases platelet aggregation. The REDUCE-IT trial (2018) showed 4g EPA reduced major cardiovascular events by 25% in high-risk patients; 2g is the evidence-supported preventive dose.
Magnesium glycinate400mg
Magnesium deficiency is associated with hypertension, arrhythmia, and elevated C-reactive protein — three independent cardiovascular risk markers. The glycinate chelate is absorbed efficiently without the GI effects of magnesium oxide or citrate, allowing consistent evening dosing. Meta-analysis by Zhang et al. 2016 (Journal of Human Hypertension): magnesium supplementation reduced systolic BP by 3–4 mmHg.
Vitamin D32000 IU
Vitamin D receptors are expressed in cardiomyocytes, vascular smooth muscle cells, and endothelium. Low D3 is an independent predictor of cardiovascular events. D3 regulates renin-angiotensin system activity and reduces cardiac inflammation — two pathways that become critical post-menopause when estrogen no longer buffers them. Supplementation targets serum levels above 40 ng/mL.
Garlic extract (Kyolic aged)600mg
Kyolic aged garlic extract is the standardized form with the strongest cardiovascular RCT evidence — it is not equivalent to raw garlic or generic garlic powder. Ried et al. 2016 RCT (n=88): Kyolic 1200mg reduced arterial stiffness and blood pressure in hypertensive adults. The 600mg dose maintains the antiplatelet and vasodilatory effects without the odor compounds of fresh garlic.
N-Acetyl Cysteine (NAC)600mg
NAC is the precursor to glutathione, the primary antioxidant that protects LDL from oxidation and endothelial cells from oxidative stress. Oxidized LDL — not total LDL — is the form that initiates atherosclerotic plaque. NAC also reduces homocysteine levels: high homocysteine is an independent cardiovascular risk factor that affects up to 30% of women with hormonal irregularities.

Check with your cardiologist before starting if you are on statins (CoQ10 depletion is common and this addresses it, but confirm), anticoagulants (omega-3 and garlic at these doses have mild antiplatelet activity), or antihypertensive medications (magnesium and garlic both have modest BP-lowering effects).

“My cardiologist flagged borderline high triglycerides after I turned 52. I started Heart First alongside the dietary changes she recommended. At my 6-month follow-up my triglycerides had dropped significantly. She said the omega-3 dose I was taking was clinical-grade and exactly what she would have prescribed.”

Diane R., 53
Post-menopause · family history of CVD · Minnesota

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